| ncRNA name | OGT shRNA |
| ncRNA Category | shRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cell line ARPE-19 |
| Methods | shRNA knockdown, ELISA, chromatin immunoprecipitation (ChIP), qRT-PCR, Western blot, immunoprecipitation |
| Expression pattern | associated |
| Functional description | Hyperglycemia increased VEGF-A promoter activity and upregulated VEGF-A transcript and protein. Cellular depletion of OGT or Sp1 by shRNA significantly abrogated glucose-induced changes in VEGF-A. |
| PubMed ID | 25352121 |
| Year | 2014 |
| Title | O-GlcNAc modification of transcription factor Sp1 mediates hyperglycemia-induced VEGF-A upregulation in retinal cells. |
| Drug-related ncRNA | NA |
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